13-15В THC typically refers to the most potent delta-9 isomer, although synthetically concentrated forms of delta-8 THC are becoming increasingly common. The concentration of THC determines a cannabis productвЂ™s potency and varies widely across and within various preparations 2-4, 10, 12 THC potency of cannabis products has been observed to be increasing over time. 4, 10, 11 From a neurotropic perspective, tetrahydrocannabinol (THC) is the most important of these cannabinoids, responsible for its psychoactive effects. 6, 8, 9 Notwithstanding the gain in the social and legal acceptance of cannabis, public health concerns remain.Д¬hemical analysis of cannabis finds more than 500 compounds, of which over 120 are cannabinoids, a class of chemicals that directly interact with the nervous systemвЂ™s endogenous cannabinoid receptors. states began legalizing the substance for medical and/or recreational usage. 6 The proportion of users has increased dramatically since the early 1970s in a 2017 survey, about 45% of Americans said they had at least tried marijuana. 2-4 The dried leaves of the cannabis plant can be smoked as marijuana, which is its most common form, currently used by 12% of American adults, 5 up from 7% in 2013. 1 The plant Cannabis sativa acts as a mild sedative and mood enhancer for recreational users and is used for its analgesic and antiemetic properties in clinical applications. Cannabis is a genus of annual flowering plants found in temperate zones around the world, with a long history of use for industrial, recreational and medicinal purposes.

Cannabis sativa uses